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KRAS inhibitor Cmpd2
CAS No. ——
KRAS inhibitor Cmpd2( —— )
Catalog No. M16986 CAS No. ——
KRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameKRAS inhibitor Cmpd2
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NoteResearch use only, not for human use.
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Brief DescriptionKRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro.
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DescriptionKRAS inhibitor Cmpd2 is a small-molecule compound that blocks biochemical and cellular functions of KRASG12V with IC50 of 0.8 uM in vitro; inhibits cell proliferation in SW1990 cells with EC50 of 2.7 uM; the potency of Cmpd2 was strongly enhanced when prenylated K-RAS4B is associated with a lipid bilayer.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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TargetRas
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RecptorRas
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight446.773
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Molecular FormulaC21H21BrClN3O
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name5-bromo-N-((2R,4S)-2-(4-chlorobenzyl)piperidin-4-yl)-1H-indole-3-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Fang Z, et al. Cell Chem Biol. 2018 Aug 14. pii: S2451-9456(18)30261-7.
2. Jansen JM, et al. PLoS One. 2017 Apr 6;12(4):e0174706.
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